CST5

For the TC LID CST5, see Sable Island § Sable Island station.

Cystatin-D is a protein that in humans is encoded by the CST5 gene.^[5][6]

CST5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RN7, 1ROA
Identifiers
Aliases	CST5, cystatin D
External IDs	OMIM: 123858; MGI: 1930004; HomoloGene: 55615; GeneCards: CST5; OMA:CST5 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.21 Start 23,875,934 bp[1] End 23,879,748 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 G3 Start 149,246,977 bp[2] End 149,252,213 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland right adrenal cortex olfactory zone of nasal mucosa upper lobe of left lung left adrenal gland left adrenal cortex right lung tonsil body of pancreas muscle tissue Top expressed in parotid gland lacrimal gland submandibular gland masseter muscle lymph node sexually immature organism grey matter prosencephalon cerebrum cerebral hemisphere More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity protein binding cysteine-type endopeptidase inhibitor activity protease binding Cellular component extracellular region extracellular exosome extracellular space Biological process negative regulation of peptidase activity negative regulation of cysteine-type endopeptidase activity negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1473 58214 Ensembl ENSG00000170367 ENSMUSG00000033156 UniProt P28325 Q9JM84 RefSeq (mRNA) NM_001900 NM_021405 RefSeq (protein) NP_001891 NP_067380 Location (UCSC) Chr 20: 23.88 – 23.88 Mb Chr 2: 149.25 – 149.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity.^[6]