CST9L

Cystatin-9-like is a protein that in humans is encoded by the CST9L gene.^[5]

CST9L
Identifiers
Aliases	CST9L, CTES7B, bA218C14.1, cystatin 9-like, cystatin 9 like
External IDs	OMIM: 616536; MGI: 1340053; HomoloGene: 49222; GeneCards: CST9L; OMA:CST9L - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.21 Start 23,564,732 bp[1] End 23,568,484 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 G3 Start 148,677,067 bp[2] End 148,680,658 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis corpus epididymis caput epididymis metanephros duodenum mammary gland female breast lactiferous gland Top expressed in seminiferous tubule Gonadal ridge spermatocyte spermatogonium spermatid epithelium of seminiferous tubule of testis Sertoli cell gastrula Ileal epithelium atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity protein binding protease binding cysteine-type endopeptidase inhibitor activity Cellular component extracellular region extracellular space Biological process negative regulation of peptidase activity negative regulation of cysteine-type endopeptidase activity negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 128821 13013 Ensembl ENSG00000101435 ENSMUSG00000027445 UniProt Q9H4G1 Q9Z0H6 RefSeq (mRNA) NM_080610 NM_009979 RefSeq (protein) NP_542177 NP_034109 Location (UCSC) Chr 20: 23.56 – 23.57 Mb Chr 2: 148.68 – 148.68 Mb PubMed search [3] [4]
Wikidata
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The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to mouse cystatin 9. Based on its testis-specific expression, it is likely to have a role in tissue reorganization during early testis development.^[5]