CTNNBIP1

Beta-catenin-interacting protein 1 is a protein that is encoded in humans by the CTNNBIP1 gene.^[5][6]

CTNNBIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M1E, 1T08
Identifiers
Aliases	CTNNBIP1, ICAT, catenin beta interacting protein 1
External IDs	OMIM: 607758; MGI: 1915756; HomoloGene: 10641; GeneCards: CTNNBIP1; OMA:CTNNBIP1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 9,848,276 bp[1] End 9,910,336 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 149,602,693 bp[2] End 149,650,894 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen skin of thigh skin of arm nipple apex of heart human penis skin of hip olfactory zone of nasal mucosa paraflocculus of cerebellum Top expressed in saccule habenula otic placode lip esophagus otic vesicle skin of external ear ventricular zone medial ganglionic eminence neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function beta-catenin binding protein binding armadillo repeat domain binding Cellular component cytoplasm cytosol nucleoplasm nucleus beta-catenin destruction complex Biological process negative regulation of smooth muscle cell proliferation negative regulation of protein-containing complex assembly negative regulation of DNA binding negative regulation of Wnt signaling pathway regulation of vascular permeability involved in acute inflammatory response negative regulation of transcription by RNA polymerase II Wnt signaling pathway negative regulation of protein binding negative regulation of DNA-binding transcription factor activity branching involved in ureteric bud morphogenesis positive regulation of osteoblast differentiation positive regulation of monocyte differentiation negative regulation of transcription initiation from RNA polymerase II promoter negative regulation of mesenchymal cell proliferation anterior/posterior pattern specification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56998 67087 Ensembl ENSG00000178585 ENSMUSG00000028988 UniProt Q9NSA3 Q9JJN6 RefSeq (mRNA) NM_020248 NM_001012329 NM_001141930 NM_023465 RefSeq (protein) NP_001012329 NP_064633 NP_001135402 NP_075954 Location (UCSC) Chr 1: 9.85 – 9.91 Mb Chr 4: 149.6 – 149.65 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF (T-cell transcription factor) family members. The encoded protein is a negative regulator of the Wnt signaling pathway.^[5]