CXCL17

Chemokine (C-X-C motif) ligand 17 (CXCL17) is a small cytokine initially thought to belong to the CXC chemokine family, then addressed as chemokine-like protein, that has been identified in humans and mice.

chemokine (C-X-C motif) ligand 7
Identifiers
Symbol	CXCL17
Alt. symbols	SCYB17, VCC-1, DMC
NCBI gene	284340
RefSeq	NM_198477
UniProt	Q6UXB2
Other data
Locus	Chr. 19 q13.2
Search for Structures Swiss-model Domains InterPro

CXCL17 has been previously reported to attract dendritic cells and monocytes, but there are also studies not reporting this activity^[1]; it is also regulated in tumors. It was formerly known as VEGF co-regulated chemokine 1 (VCC-1) and dendritic cell- and monocyte-attracting chemokine-like protein (DMC).^[2][3] This chemokine is constitutively expressed in the respiratory tract and more specifically in the lung.^[3] The gene for human CXCL17 is located on chromosome 19.^[3] Human and murine CXCL17 protein share 71% of amino acid sequence identity ^[4].

Function

Being expressed in the respiratory tract mucosa, CXCL17 is likely to exert functions related to both immune surveillance of the tissue by fostering immune activation and immune suppression in case of overactivation of the immune system against harmless environmental antigens that can be commonly inhaled. CXCL17 also shows some anti-microbial activity against some bacteria, such as E.coli, S. aureus, Salmonella, P. aeruginosa and C. albicans strains.

Receptor

The receptor for CXCL17 is a G protein-coupled receptor (GPCR). The GPCR GPR35 was thought to be a receptor of CXCL17 ^[5] Subsequent research has suggested that GPR35 is not a receptor for CXCL17.^[6][7]. Indeed, recently GPR25 has been uniquely identified as CXCL17 receptor ^[8]