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GPR25

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

GPR25
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Probable G-protein coupled receptor 25 is a protein that in humans is encoded by the GPR25 gene.[5][6]

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Structure

It is a member of the G protein-coupled receptor (GPCR) family and it's well conserved in vertebrate evolution containing a canonical DRYLAVV motif in the third transmembrane sequence. It has a conserved negatively charged N-terminal extracellular peptide comprising a DY candidate sulfation site that is characteristic of many leukocyte chemoattractant receptors for positively charged polypeptides of the chemokine family.[7]

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Tissue distribution

GPR25 expression is largely restricted to lymphocytes and natural killer (NK) cells.[7]

Function

It has been identified as the receptor for the chemokine-like protein CXCL17.[7]

References

Further reading

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