CXCL6

Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes.^[5][6] It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2.^[6] The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.^[7][8]

CXCL6
Identifiers
Aliases	CXCL6, CKA-3, GCP-2, GCP2, SCYB6, C-X-C motif chemokine ligand 6
External IDs	OMIM: 138965; MGI: 1096868; HomoloGene: 88671; GeneCards: CXCL6; OMA:CXCL6 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 73,836,640 bp[1] End 73,849,064 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E1|5 44.78 cM Start 90,907,219 bp[2] End 90,909,483 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell palpebral conjunctiva spleen olfactory zone of nasal mucosa cartilage tissue islet of Langerhans beta cell parietal pleura jejunal mucosa sperm Top expressed in right lobe of liver cervix endothelial cell of lymphatic vessel trachea respiratory epithelium olfactory epithelium mandibular molars embryo embryo conjunctival fornix More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity CXCR chemokine receptor binding heparin binding chemokine activity protein binding Cellular component extracellular region extracellular space Biological process chemotaxis cell-cell signaling chemokine-mediated signaling pathway regulation of cell population proliferation defense response to bacterium signal transduction neutrophil mediated immunity defense response positive regulation of neutrophil chemotaxis neutrophil chemotaxis neutrophil activation antimicrobial humoral immune response mediated by antimicrobial peptide cellular response to lipopolysaccharide inflammatory response immune response regulation of signaling receptor activity G protein-coupled receptor signaling pathway leukocyte homeostasis leukocyte chemotaxis response to lipopolysaccharide regulation of chemokine production regulation of neutrophil mediated killing of gram-negative bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6372 20311 Ensembl ENSG00000124875 ENSMUSG00000029371 UniProt P80162 P50228 RefSeq (mRNA) NM_002993 NM_009141 RefSeq (protein) NP_002984 NP_033167 Location (UCSC) Chr 4: 73.84 – 73.85 Mb Chr 5: 90.91 – 90.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
Identifiers
Symbol	CXCL6
Alt. symbols	SCYB6, GCP-2, CKA-3
NCBI gene	6372
HGNC	10643
OMIM	138965
RefSeq	NM_002993
UniProt	P80162
Other data
Locus	Chr. 4 q21
Search for Structures Swiss-model Domains InterPro