CYB5R1

NADH-cytochrome b5 reductase 1 is an enzyme that in humans is encoded by the CYB5R1 gene.^[5][6][7]

CYB5R1
Identifiers
Aliases	CYB5R1, B5R.1, B5R1, B5R2, NQO3A2, humb5R2, cytochrome b5 reductase 1
External IDs	OMIM: 608341; MGI: 1919267; HomoloGene: 96059; GeneCards: CYB5R1; OMA:CYB5R1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 202,961,873 bp[1] End 202,967,275 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 134,333,297 bp[2] End 134,339,478 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of biceps brachii gastrocnemius muscle glutes muscle of thigh deltoid muscle vastus lateralis muscle body of tongue Skeletal muscle tissue of rectus abdominis triceps brachii muscle tibialis anterior muscle Top expressed in stroma of bone marrow plantaris muscle triceps brachii muscle temporal muscle vastus lateralis muscle calvaria extraocular muscle sternocleidomastoid muscle muscle of thigh digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cytochrome-b5 reductase activity, acting on NAD(P)H oxidoreductase activity FAD binding Cellular component integral component of membrane extracellular exosome plasma membrane endoplasmic reticulum membrane membrane mitochondrion platelet alpha granule membrane Biological process steroid metabolic process sterol biosynthetic process positive regulation of protein targeting to mitochondrion lipid metabolism steroid biosynthetic process platelet degranulation bicarbonate transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51706 72017 Ensembl ENSG00000159348 ENSMUSG00000026456 UniProt Q9UHQ9 Q9DB73 RefSeq (mRNA) NM_016243 NM_028057 NM_001355133 RefSeq (protein) NP_057327 NP_082333 NP_001342062 Location (UCSC) Chr 1: 202.96 – 202.97 Mb Chr 1: 134.33 – 134.34 Mb PubMed search [3] [4]
Wikidata
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Structure

The CYB5R1 gene is located on the 1st chromosome, with its specific location being 1q32.1. The gene contains 9 exons.^[7] CYB5R1 encodes a 34.1 kDa protein that is composed of 305 amino acids; 56 peptides have been observed through mass spectrometry data.^[8][9]