CYB5R4

Cytochrome b5 reductase 4 is an enzyme that in humans is encoded by the CYB5R4 gene.^[5][6]

CYB5R4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LF5
Identifiers
Aliases	CYB5R4, NCB5OR, cb5/cb5R, dJ676J13.1, cytochrome b5 reductase 4
External IDs	OMIM: 608343; MGI: 2386848; HomoloGene: 69207; GeneCards: CYB5R4; OMA:CYB5R4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q14.2 Start 83,859,656 bp[1] End 83,967,423 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.1 Start 86,904,067 bp[2] End 86,959,827 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte sperm blood bone marrow granulocyte bone marrow cells right testis left testis appendix islet of Langerhans Top expressed in granulocyte ileum ganglionic eminence jejunum zygote quadriceps femoris muscle duodenum neural tube tail of embryo ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity NAD(P)H oxidase H2O2-forming activity oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor heme binding metal ion binding cytochrome-b5 reductase activity, acting on NAD(P)H Cellular component perinuclear region of cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Biological process response to antibiotic insulin secretion detection of oxygen generation of precursor metabolites and energy glucose homeostasis superoxide metabolic process cell development bicarbonate transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51167 266690 Ensembl ENSG00000065615 ENSMUSG00000032872 UniProt Q7L1T6 Q3TDX8 RefSeq (mRNA) NM_016230 NM_024195 NM_001359962 RefSeq (protein) NP_057314 NP_077157 NP_001346891 Location (UCSC) Chr 6: 83.86 – 83.97 Mb Chr 9: 86.9 – 86.96 Mb PubMed search [3] [4]
Wikidata
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NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5; MIM 250790) and CYB5 reductase (DIA1; MIM 250800).[supplied by OMIM]^[6]