CYP26A1

Cytochrome P450 26A1 is a protein that in humans is encoded by the CYP26A1 gene.^[5][6][7]

CYP26A1
Identifiers
Aliases	CYP26A1, CP26, CYP26, P450RAI, P450RAI1, cytochrome P450 family 26 subfamily A member 1
External IDs	OMIM: 602239; MGI: 1096359; HomoloGene: 37349; GeneCards: CYP26A1; OMA:CYP26A1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.33 Start 93,073,475 bp[1] End 93,077,885 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C2 Start 37,686,246 bp[2] End 37,689,984 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver olfactory zone of nasal mucosa gonad placenta endometrium prefrontal cortex superior frontal gyrus Brodmann area 9 anterior cingulate cortex right frontal lobe Top expressed in molar tail of embryo otic vesicle epithelium of lens primitive streak otic placode epiblast embryo left lobe of liver embryonic cloaca More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding oxygen binding oxidoreductase activity retinoic acid binding heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen retinoic acid 4-hydroxylase activity Cellular component organelle membrane endoplasmic reticulum membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle Biological process negative regulation of retinoic acid receptor signaling pathway retinoic acid catabolic process vitamin metabolic process xenobiotic metabolic process sterol metabolic process response to retinoic acid response to vitamin A retinoic acid metabolic process kidney development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1592 13082 Ensembl ENSG00000095596 ENSMUSG00000024987 UniProt O43174 O55127 RefSeq (mRNA) NM_057157 NM_000783 NM_007811 RefSeq (protein) NP_000774 NP_476498 NP_031837 Location (UCSC) Chr 10: 93.07 – 93.08 Mb Chr 19: 37.69 – 37.69 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported.^[7]

CYP26A1 is over-expressed in colorectal cancer cells compared to normal colonic epithelium but is of no independent prognostic value in patients with colorectal cancer.^[8]