CYP2F1

Cytochrome P450 2F1 is a protein that in humans is encoded by the CYP2F1 gene.^[5]

CYP2F1
Identifiers
Aliases	CYP2F1, C2F1, CYP2F, CYPIIF1, cytochrome P450 family 2 subfamily F member 1
External IDs	OMIM: 124070; MGI: 88608; HomoloGene: 73898; GeneCards: CYP2F1; OMA:CYP2F1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 41,114,432 bp[1] End 41,128,381 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 26,819,334 bp[2] End 26,833,085 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle olfactory zone of nasal mucosa gonad stromal cell of endometrium right lung right testis left testis sural nerve minor salivary glands bone marrow Top expressed in right lung right lung lobe olfactory system olfactory epithelium left lobe of liver lacrimal gland conjunctival fornix parotid gland esophagus left lung More reference expression data BioGPS n/a
Gene ontology Molecular function iron ion binding oxygen binding arachidonic acid epoxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen metal ion binding monooxygenase activity heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity aromatase activity steroid hydroxylase activity Cellular component organelle membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle membrane endoplasmic reticulum cytoplasm Biological process epoxygenase P450 pathway trichloroethylene metabolic process xenobiotic metabolic process response to toxic substance organic acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1572 13107 Ensembl ENSG00000197446 ENSMUSG00000052974 UniProt P24903 P33267 RefSeq (mRNA) NM_000774 NM_007817 RefSeq (protein) NP_000765 NP_031843 Location (UCSC) Chr 19: 41.11 – 41.13 Mb Chr 7: 26.82 – 26.83 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates, such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.^[5]