Calcium modulating ligand

Calcium modulating ligand (CAMLG or CAML), also known as calcium-modulating cyclophilin ligand, is a signalling protein recognized by the TNF receptor TACI.^[5][6]

CAMLG
Identifiers
Aliases	CAMLG, CAML, GET2, calcium modulating ligand
External IDs	OMIM: 601118; MGI: 104728; HomoloGene: 1323; GeneCards: CAMLG; OMA:CAMLG - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 134,738,495 bp[1] End 134,752,157 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 B1|13 30.06 cM Start 55,770,818 bp[2] End 55,780,224 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sperm Brodmann area 23 cartilage tissue ganglionic eminence trigeminal ganglion Achilles tendon superior vestibular nucleus nipple Brodmann area 9 Top expressed in medial ganglionic eminence spermatocyte condyle neural layer of retina fossa facial motor nucleus saccule substantia nigra trigeminal ganglion ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cell adhesion molecule binding ubiquitin protein ligase binding Cellular component integral component of membrane endoplasmic reticulum membrane cytoplasm Biological process defense response viral process receptor recycling epidermal growth factor receptor signaling pathway signal transduction negative regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process protein stabilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 819 12328 Ensembl ENSG00000164615 ENSMUSG00000021501 UniProt P49069 P49070 RefSeq (mRNA) NM_001745 NM_007596 RefSeq (protein) NP_001736 NP_031622 Location (UCSC) Chr 5: 134.74 – 134.75 Mb Chr 13: 55.77 – 55.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.^[6]

Interactions

CAMLG has been shown to interact with TNFRSF13B.^[7][8]