Caldesmon

Caldesmon is a protein that in humans is encoded by the CALD1 gene.^[3][4]

CALD1
Identifiers
Aliases	CALD1, CDM, H-CAD, HCAD, L-CAD, LCAD, NAG22, caldesmon 1, h-CD
External IDs	OMIM: 114213; HomoloGene: 137424; GeneCards: CALD1; OMA:CALD1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q33 Start 134,744,252 bp[1] End 134,970,729 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein tail of epididymis seminal vesicula tendon of biceps brachii urethra superficial temporal artery visceral pleura parietal pleura stromal cell of endometrium right coronary artery n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function myosin binding actin binding tropomyosin binding protein binding calmodulin binding cadherin binding Cellular component cytoplasm cytosol plasma membrane myofibril cytoskeleton actin cytoskeleton intracellular membrane-bounded organelle membrane actin cap Biological process muscle contraction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 800 n/a Ensembl ENSG00000122786 n/a UniProt Q05682 n/a RefSeq (mRNA) NM_004342 NM_033138 NM_033139 NM_033140 NM_033157 n/a RefSeq (protein) NP_004333 NP_149129 NP_149130 NP_149131 NP_149347 n/a Location (UCSC) Chr 7: 134.74 – 134.97 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle.

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to ${\displaystyle {\text{Ca}}^{2+}}$-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for ${\displaystyle {\text{Ca}}^{2+}}$-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.^[4]

Immunochemistry

In diagnostic immunochemistry, caldesmon is a marker for smooth muscle differentiation.