Calgranulin

Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and neutrophils.

Calgranulin C hexamer, Human.

The proteins S100A8 and S100A9 form a heterodimer called calprotectin.

Human genes

• S100A8 (calgranulin A)
• S100A9 (calgranulin B)
• S100A12 (calgranulin C)

Function

Some in vitro evidence suggests that calgranulin can inhibit the precipitation of calcium oxalate in a urine-like environment at calgranulin concentrations below physiological concentrations.^[1] Thus, it may also function in vivo as an inhibitor of calcium oxalate kidney stone formation. However, the role of calgranulin in the stone formation process has not been evaluated.

See also

• Measurement of faecal calprotectin