S100A8

S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene.^[5] It is also known as calgranulin A.

S100A8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MR8, 1XK4, 4GGF, 4XJK, 5HLO, 5HLV
Identifiers
Aliases	S100A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, S100 calcium binding protein A8, S100-A8
External IDs	OMIM: 123885; MGI: 88244; HomoloGene: 2225; GeneCards: S100A8; OMA:S100A8 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,390,032 bp[1] End 153,391,073 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.9 cM Start 90,576,285 bp[2] End 90,577,342 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of pharynx gums body of tongue oral cavity trabecular bone gingival epithelium periodontal fiber monocyte bone marrow vulva Top expressed in granulocyte tibiofemoral joint gastrula femur body of femur fetal liver hematopoietic progenitor cell decidua human fetus spleen blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function Toll-like receptor 4 binding RAGE receptor binding microtubule binding protein binding calcium ion binding arachidonic acid binding zinc ion binding metal ion binding Cellular component nucleus cytoskeleton cytosol extracellular exosome membrane plasma membrane cytoplasm extracellular space secretory granule lumen intermediate filament cytoskeleton extracellular region collagen-containing extracellular matrix Biological process regulation of inflammatory response activation of cysteine-type endopeptidase activity involved in apoptotic process immune system process positive regulation of inflammatory response neutrophil chemotaxis positive regulation of intrinsic apoptotic signaling pathway defense response to fungus response to ethanol chemokine production response to zinc ion acute inflammatory response defense response to bacterium leukocyte migration involved in inflammatory response peptidyl-cysteine S-nitrosylation sequestering of zinc ion neutrophil aggregation response to lipopolysaccharide chemotaxis positive regulation of peptide secretion chronic inflammatory response astrocyte development wound healing apoptotic process positive regulation of cell growth autophagy inflammatory response regulation of cytoskeleton organization cytokine production positive regulation of NF-kappaB transcription factor activity innate immune response toll-like receptor signaling pathway antimicrobial humoral response neutrophil degranulation autocrine signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6279 20201 Ensembl ENSG00000143546 ENSMUSG00000056054 UniProt P05109 P27005 RefSeq (mRNA) NM_002964 NM_001319196 NM_001319197 NM_001319198 NM_001319201 NM_013650 RefSeq (protein) NP_001306125 NP_001306126 NP_001306127 NP_001306130 NP_002955 NP_038678 Location (UCSC) Chr 1: 153.39 – 153.39 Mb Chr 3: 90.58 – 90.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The proteins S100A8 and S100A9 form a heterodimer called calprotectin.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis ^[5] and post COVID-19 condition.^[6]