Cardiotrophin 1

Cardiotrophin-1 (CT-1) is a cytokine. It is a cardiac hypertrophic factor of 21.5 kDa and a protein member of the IL-6 cytokine family.

cardiotrophin 1
Identifiers
Symbol	CTF1, CT1, CT-1
NCBI gene	1489
HGNC	2499
OMIM	600435
RefSeq	NM_001330
UniProt	Q16619
Other data
Locus	Chr. 16 p11.2-16p11.1
Search for Structures Swiss-model Domains InterPro

Pathology

CT-1 is associated with the pathophysiology of heart diseases, including hypertension, myocardial infarction, valvular heart disease, and congestive heart failure.

Mode of action

The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-κB DNA -binding activities.

CT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine. ^[1]