Caspase 4

Caspase 4 is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue (LEVD-), and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and the murine homolog caspase 11), with a role in the immune system.^[1]

caspase 4, apoptosis-related cysteine peptidase
Identifiers
Symbol	CASP4
Alt. symbols	ICE(rel)II, ICH-2, TX
NCBI gene	837
HGNC	1505
OMIM	602664
RefSeq	NM_001225
UniProt	P49662
Other data
EC number	3.4.22.57
Locus	Chr. 11 q22.2-q22.3
Search for Structures Swiss-model Domains InterPro

The anti-inflammatory drug indoprofen is an inhibitor of the activity of the caspase-4 enzyme.^[2]

See also

• The Proteolysis Map
• Caspase