CatSper3

CatSper3, is a protein which in humans is encoded by the CATSPER3 gene.^[5][6][7][8] CatSper3 is a member of the cation channels of sperm family of proteins. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.^[9]

CATSPER3
Identifiers
Aliases	CATSPER3, CACRC, CatSper3, cation channel sperm associated 3
External IDs	OMIM: 609120; MGI: 1924106; HomoloGene: 12658; GeneCards: CATSPER3; OMA:CATSPER3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 134,967,907 bp[1] End 135,011,696 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 55,932,381 bp[2] End 55,956,811 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm right testis left testis testicle gonad gastrocnemius muscle muscle of thigh right uterine tube mucosa of transverse colon gastric mucosa Top expressed in spermatid seminiferous tubule embryo spermatocyte embryo primary oocyte muscle of thigh zygote proximal tubule digastric muscle More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated calcium channel activity calcium channel activity voltage-gated ion channel activity ion channel activity cation channel activity Cellular component integral component of membrane CatSper complex cell projection membrane plasma membrane cilium acrosomal vesicle endoplasmic reticulum motile cilium Biological process flagellated sperm motility cell differentiation membrane depolarization during action potential sodium ion transport regulation of ion transmembrane transport ion transport multicellular organism development ion transmembrane transport calcium ion transmembrane transport transmembrane transport spermatogenesis sperm-egg recognition sperm capacitation calcium ion transport response to progesterone Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 347732 76856 Ensembl ENSG00000152705 ENSMUSG00000021499 UniProt Q86XQ3 Q80W99 RefSeq (mRNA) NM_178019 NM_001252487 NM_001252488 NM_029772 RefSeq (protein) NP_821138 NP_001239416 NP_001239417 NP_084048 Location (UCSC) Chr 5: 134.97 – 135.01 Mb Chr 13: 55.93 – 55.96 Mb PubMed search [3] [4]
Wikidata
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