CatSper4

CatSper4, is a protein which in humans is encoded by the CATSPER4 gene.^[5][6][7] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.^[8]

CATSPER4
Identifiers
Aliases	CATSPER4, CatSper4, cation channel sperm associated 4
External IDs	OMIM: 609121; MGI: 3043288; HomoloGene: 18638; GeneCards: CATSPER4; OMA:CATSPER4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 26,190,561 bp[1] End 26,202,968 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.3 Start 133,939,281 bp[2] End 133,954,694 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis muscle of thigh gastrocnemius muscle skeletal muscle tissue mucosa of transverse colon right uterine tube lobe of thyroid gland left lobe of thyroid gland tibial nerve Top expressed in spermatid testicle spermatocyte muscle of thigh neural layer of retina embryo muscle tissue quadriceps femoris muscle jejunum skeletal muscle tissue More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated calcium channel activity calcium activated cation channel activity calcium channel activity voltage-gated ion channel activity ion channel activity NAADP-sensitive calcium-release channel activity Cellular component integral component of membrane CatSper complex cell projection membrane plasma membrane cilium sperm principal piece acrosomal vesicle motile cilium Biological process flagellated sperm motility cell differentiation membrane depolarization during action potential sodium ion transport regulation of ion transmembrane transport ion transport multicellular organism development calcium ion transmembrane transport transmembrane transport spermatogenesis sperm-egg recognition sperm capacitation release of sequestered calcium ion into cytosol calcium ion transport response to progesterone Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 378807 329954 Ensembl ENSG00000188782 ENSMUSG00000048003 UniProt Q7RTX7 Q8BVN3 RefSeq (mRNA) NM_198137 NM_001130030 NM_177866 RefSeq (protein) NP_937770 NP_001123502 NP_808534 Location (UCSC) Chr 1: 26.19 – 26.2 Mb Chr 4: 133.94 – 133.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse