Cathepsin W

Cathepsin W is a protein that in humans is encoded by the CTSW gene.^[5][6][7]

CTSW
Identifiers
Aliases	CTSW, LYPN, cathepsin W
External IDs	OMIM: 602364; MGI: 1338045; HomoloGene: 37471; GeneCards: CTSW; OMA:CTSW - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,879,809 bp[1] End 65,883,741 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,515,071 bp[2] End 5,518,535 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood bone marrow cell spleen decidua mononuclear cell monocyte lymph node upper lobe of left lung right lung Top expressed in mesenteric lymph nodes blood thymus spleen embryo subcutaneous adipose tissue pharynx duodenum embryo granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity cysteine-type endopeptidase activity cysteine-type peptidase activity hydrolase activity Cellular component lysosome membrane platelet dense granule lumen extracellular region extracellular space endoplasmic reticulum Biological process proteolysis involved in cellular protein catabolic process immune response proteolysis platelet degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1521 13041 Ensembl ENSG00000172543 ENSMUSG00000024910 UniProt P56202 P56203 RefSeq (mRNA) NM_001335 NM_009985 RefSeq (protein) NP_001326 NP_034115 Location (UCSC) Chr 11: 65.88 – 65.88 Mb Chr 19: 5.52 – 5.52 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene, a member of the peptidase C1 family of cysteine cathepsins, is a cysteine protease cathepsin that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the cell membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.^[7]