Cerebral dopamine neurotrophic factor

Cerebral dopamine neurotrophic factor also known as ARMET-like protein 1 is a protein that in humans is encoded by the CDNF gene.^[5][6]

CDNF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LPN, 2W50, 4BIT
Identifiers
Aliases	CDNF, ARMETL1, cerebral dopamine neurotrophic factor
External IDs	OMIM: 611233; MGI: 3606576; HomoloGene: 27965; GeneCards: CDNF; OMA:CDNF - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p13 Start 14,819,245 bp[1] End 14,838,575 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A1 Start 3,514,067 bp[2] End 3,527,413 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle left testis right testis sperm right uterine tube testicle Achilles tendon olfactory zone of nasal mucosa gonad Top expressed in quadriceps femoris muscle muscle of thigh skeletal muscle tissue esophagus spermatocyte zone of skin urinary bladder lip white adipose tissue embryo More reference expression data BioGPS n/a
Gene ontology Molecular function growth factor activity Cellular component extracellular region extracellular space endoplasmic reticulum Biological process neuron projection development dopaminergic neuron differentiation regulation of signaling receptor activity signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 441549 227526 Ensembl ENSG00000185267 ENSMUSG00000039496 UniProt Q49AH0 Q8CC36 RefSeq (mRNA) NM_001029954 NM_177647 RefSeq (protein) NP_001025125 NP_808315 Location (UCSC) Chr 10: 14.82 – 14.84 Mb Chr 2: 3.51 – 3.53 Mb PubMed search [3] [4]
Wikidata
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In preclinical models, localized injections of CDNF prevent and restore 6-OHDA induced dopaminergic lesions.^[6]