Chymotrypsin-C

Chymotrypsin C, also known as caldecrin or elastase 4, is an enzyme that in humans is encoded by the CTRC gene.^[5][6]

CTRC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H4F
Identifiers
Aliases	CTRC, CLCR, ELA4, chymotrypsin C
External IDs	OMIM: 601405; MGI: 1923951; HomoloGene: 21422; GeneCards: CTRC; OMA:CTRC - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.21 Start 15,438,442 bp[1] End 15,449,242 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 141,565,550 bp[2] End 141,573,670 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans pancreatic epithelial cell beta cell pancreatic ductal cell right coronary artery ectocervix Descending thoracic aorta granulocyte right lobe of liver Top expressed in pyloric antrum pancreas islet of Langerhans embryo embryo morula duodenum blastocyst mesenteric lymph nodes spleen More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity serine-type peptidase activity serine-type endopeptidase activity protein binding hydrolase activity Cellular component extracellular region Biological process cobalamin metabolic process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11330 76701 Ensembl ENSG00000162438 ENSMUSG00000062478 UniProt Q99895 Q3SYP2 RefSeq (mRNA) NM_007272 NM_001033875 RefSeq (protein) NP_009203 NP_001029047 Location (UCSC) Chr 1: 15.44 – 15.45 Mb Chr 4: 141.57 – 141.57 Mb PubMed search [3] [4]
Wikidata
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Function

Chymotrypsin C is a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity.^[5]