Complement component 6

Complement component 6 is a protein that in humans is encoded by the C6 gene.^[5]

C6
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3T5O, 4A5W, 4E0S
Identifiers
Aliases	C6, complement C6
External IDs	OMIM: 217050; MGI: 88233; HomoloGene: 47; GeneCards: C6; OMA:C6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p13.1 Start 41,142,116 bp[1] End 41,261,438 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 A1|15 1.97 cM Start 4,756,657 bp[2] End 4,844,449 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right ventricle cardiac muscle tissue of right atrium right uterine tube myocardium of left ventricle right auricle of heart body of pancreas bronchial epithelial cell pancreatic ductal cell apex of heart Top expressed in left lobe of liver mesenteric lymph nodes right lung lobe left lung left lung lobe white adipose tissue spleen mucosa of small intestine subcutaneous adipose tissue embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component extracellular region extracellular exosome membrane attack complex Biological process positive regulation of activation of membrane attack complex immune system process complement activation in utero embryonic development cytolysis regulation of complement activation immune response positive regulation of angiogenesis complement activation, classical pathway positive regulation of complement activation innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 729 12274 Ensembl ENSG00000039537 ENSMUSG00000022181 UniProt P13671 n/a RefSeq (mRNA) NM_000065 NM_001115131 NM_016704 RefSeq (protein) NP_000056 NP_001108603 n/a Location (UCSC) Chr 5: 41.14 – 41.26 Mb Chr 15: 4.76 – 4.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Complement component 6 is a protein involved in the complement system. It is part of the membrane attack complex which can insert into the cell membrane and cause the cell to lyse.

People with C6 deficiency are prone to bacterial infection.^[5]