Complement component 7

Complement component 7 is a protein involved in the complement system of the innate immune system. C7 is part of the membrane attack complex (MAC) which creates a hole on pathogen surfaces, leading to cell lysis and death.

C7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WCY
Identifiers
Aliases	C7, complement component 7, complement C7
External IDs	OMIM: 217070; MGI: 88235; HomoloGene: 489; GeneCards: C7; OMA:C7 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p13.1 Start 40,909,492 bp[1] End 40,984,643 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 A1|15 1.98 cM Start 5,018,244 bp[2] End 5,093,222 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ovary superficial temporal artery pericardium right adrenal cortex gastric mucosa left adrenal gland left adrenal cortex gallbladder right auricle of heart right coronary artery Top expressed in zone of skin spermatid esophagus lung testicle spermatocyte white adipose tissue skeletal muscle tissue adrenal gland quadriceps femoris muscle More reference expression data BioGPS n/a
Gene ontology Molecular function growth factor activity Cellular component extracellular region extracellular exosome membrane attack complex Biological process complement activation cytolysis regulation of complement activation complement activation, alternative pathway immune response complement activation, classical pathway immune system process innate immune response cellular sodium ion homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 730 109828 Ensembl ENSG00000112936 ENSMUSG00000079105 UniProt P10643 D3YXF5 RefSeq (mRNA) NM_000587 NM_001243837 RefSeq (protein) NP_000578 NP_001230766 Location (UCSC) Chr 5: 40.91 – 40.98 Mb Chr 15: 5.02 – 5.09 Mb PubMed search [3] [4]
Wikidata
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Its primary task is to bind the C5bC6 complex together. This junction alters the configuration of the protein molecules, exposing a hydrophobic site on C7 that allows the C7 to insert into the phospholipid bilayer of the pathogen.

See also

• Terminal complement pathway deficiency

External links

• Complement+C7 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: P10643 (Human Complement component C7) at the PDBe-KB.