Cyclic nucleotide-gated channel alpha 1

Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein.^[5] Heterologously expressed CNGA1 can form a functional channel that is permeable to calcium.^[6] In rod photoreceptors, however, CNGA1 forms a heterotetramer with CNGB1 in a 3:1 ratio.^[7][8][9] The addition of the CNGB1 channel imparts altered properties including more rapid channel kinetics and greater cAMP-activated current.^[10] When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/B1 channels and, therefore, hyperpolarization of the membrane potential.

CNGA1
Identifiers
Aliases	CNGA1, CNCG, CNCG1, CNG-1, CNG1, RCNC1, RCNCa, RCNCalpha, RP49, Cyclic nucleotide-gated channel alpha 1, cyclic nucleotide gated channel alpha 1, cyclic nucleotide gated channel subunit alpha 1
External IDs	OMIM: 123825; MGI: 88436; HomoloGene: 55432; GeneCards: CNGA1; OMA:CNGA1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p12 Start 47,935,977 bp[1] End 48,016,681 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C3.2|5 38.44 cM Start 72,761,039 bp[2] End 72,801,618 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid right lobe of liver sural nerve pancreatic epithelial cell testicle pancreatic ductal cell mucosa of urinary bladder skin of abdomen skin of hip corpus epididymis Top expressed in neural layer of retina retinal pigment epithelium epithelium of lens ciliary body iris thymus corneal stroma zygote conjunctival fornix secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding intracellular cyclic nucleotide activated cation channel activity ion channel activity protein binding voltage-gated potassium channel activity cGMP binding intracellular cAMP-activated cation channel activity intracellular cGMP-activated cation channel activity Cellular component integral component of membrane membrane plasma membrane photoreceptor outer segment integral component of plasma membrane photoreceptor outer segment membrane Biological process response to stimulus regulation of rhodopsin mediated signaling pathway regulation of membrane potential ion transport cation transmembrane transport transmembrane transport visual perception rhodopsin mediated signaling pathway potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1259 12788 Ensembl ENSG00000198515 ENSMUSG00000067220 UniProt P29973 P29974 RefSeq (mRNA) NM_000087 NM_001142564 NM_001379270 NM_007723 RefSeq (protein) NP_000078 NP_001136036 NP_001366199 NP_000078.2 NP_031749 Location (UCSC) Chr 4: 47.94 – 48.02 Mb Chr 5: 72.76 – 72.8 Mb PubMed search [3] [4]
Wikidata
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See also

• Cyclic nucleotide-gated ion channel