Cyclin dependent kinase like 1

Cyclin dependent kinase like 1 is a protein that in humans is encoded by the CDKL1 gene. ^[5]

CDKL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AGU
Identifiers
Aliases	CDKL1, KKIALRE, P42, cyclin dependent kinase like 1
External IDs	OMIM: 603441; MGI: 1918341; HomoloGene: 55805; GeneCards: CDKL1; OMA:CDKL1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q21.3 Start 50,326,265 bp[1] End 50,416,461 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C2 Start 69,793,622 bp[2] End 69,838,041 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube Achilles tendon canal of the cervix body of uterus ectocervix epithelium of colon muscle layer of sigmoid colon right lobe of thyroid gland left ovary monocyte Top expressed in right kidney human kidney lumbar subsegment of spinal cord spermatid spermatocyte dentate gyrus of hippocampal formation granule cell blood visual cortex primary visual cortex superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding kinase activity cyclin-dependent protein serine/threonine kinase activity Cellular component cytoplasm extracellular exosome nucleus nucleoplasm intracellular membrane-bounded organelle ciliary transition zone Biological process heart development phosphorylation regulation of cell cycle protein phosphorylation regulation of cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8814 71091 Ensembl ENSG00000100490 ENSMUSG00000020990 UniProt Q00532 Q8CEQ0 RefSeq (mRNA) NM_001282236 NM_004196 NM_001367064 NM_001367065 NM_183294 RefSeq (protein) NP_001269165 NP_004187 NP_001353993 NP_001353994 NP_899117 Location (UCSC) Chr 14: 50.33 – 50.42 Mb Chr 12: 69.79 – 69.84 Mb PubMed search [3] [4]
Wikidata
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Function

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus, and two transcript variants encoding different isoforms have been found for this gene.