DACH2

Dachshund homolog 2 is a protein that in humans is encoded by the DACH2 gene.^[5]

DACH2
Identifiers
Aliases	DACH2, dachshund family transcription factor 2
External IDs	OMIM: 300608; MGI: 1890446; HomoloGene: 33472; GeneCards: DACH2; OMA:DACH2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq21.2 Start 86,148,451 bp[1] End 86,832,604 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X E1|X 49.13 cM Start 112,207,207 bp[2] End 112,746,083 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus entorhinal cortex superior frontal gyrus postcentral gyrus nucleus accumbens ventricular zone hippocampus proper prefrontal cortex Top expressed in vas deferens vestibular membrane of cochlear duct saccule otic vesicle genital tubercle digastric muscle vestibular sensory epithelium iris medial ganglionic eminence urachus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II general transcription initiation factor activity Cellular component nucleus transcription regulator complex Biological process development of primary female sexual characteristics transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development RNA polymerase II preinitiation complex assembly regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117154 93837 Ensembl ENSG00000126733 ENSMUSG00000025592 UniProt Q96NX9 Q925Q8 RefSeq (mRNA) NM_001139514 NM_001139515 NM_053281 NM_001142570 NM_001289732 NM_001289733 NM_001289734 NM_033605 RefSeq (protein) NP_001132986 NP_001132987 NP_444511 NP_001136042 NP_001276661 NP_001276662 NP_001276663 NP_291083 Location (UCSC) Chr X: 86.15 – 86.83 Mb Chr X: 112.21 – 112.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in the regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure.