DAPK2

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.^[5][6]

DAPK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WMK, 1WRZ, 1Z9X, 1ZUZ, 1ZWS, 2A27, 2A2A, 2CKE
Identifiers
Aliases	DAPK2, DRP-1, DRP1, death-associated protein kinase 2, death associated protein kinase 2
External IDs	OMIM: 616567; MGI: 1341297; HomoloGene: 74940; GeneCards: DAPK2; OMA:DAPK2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 63,907,036 bp[1] End 64,072,033 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 C|9 35.75 cM Start 66,158,223 bp[2] End 66,272,242 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland right auricle of heart right lung gastrocnemius muscle muscle of thigh upper lobe of left lung left ventricle blood sural nerve Top expressed in muscle of thigh membranous bone body of femur lumbar spinal ganglion Dermatocranium maxilla lip right lung right lung lobe tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity calmodulin binding kinase activity protein serine/threonine kinase activity protein binding identical protein binding ATP binding Cellular component cytoplasm autophagosome lumen cytoplasmic vesicle Golgi apparatus intracellular membrane-bounded organelle nucleus Biological process regulation of apoptotic process intracellular signal transduction regulation of intrinsic apoptotic signaling pathway phosphorylation protein phosphorylation positive regulation of eosinophil chemotaxis regulation of autophagy anoikis positive regulation of neutrophil chemotaxis protein autophosphorylation neutrophil migration apoptotic process peptidyl-serine phosphorylation peptidyl-threonine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23604 13143 Ensembl ENSG00000035664 ENSMUSG00000032380 UniProt Q9UIK4 Q8VDF3 RefSeq (mRNA) NM_014326 NM_001363730 NM_001384997 NM_001384998 NM_001384999 NM_001385000 NM_010019 RefSeq (protein) NP_055141 NP_001350659 NP_034149 NP_001391612 Location (UCSC) Chr 15: 63.91 – 64.07 Mb Chr 9: 66.16 – 66.27 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Gene overexpression induces cell apoptosis. It uses multiple polyadenylation sites.^[6]

The DAPK2 mRNA may undergo alternative splicing to produce a DAPK3-like encoding transcript.^[7]