DAZAP2

DAZ-associated protein 2 is a protein that in humans is encoded by the DAZAP2 gene.^[5][6][7]

DAZAP2
Identifiers
Aliases	DAZAP2, PRTB, DAZ associated protein 2
External IDs	OMIM: 607431; MGI: 1344344; HomoloGene: 8038; GeneCards: DAZAP2; OMA:DAZAP2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 51,238,724 bp[1] End 51,271,362 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F1|15 56.36 cM Start 100,513,230 bp[2] End 100,518,642 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid bronchial epithelial cell endothelial cell mucosa of sigmoid colon epithelium of nasopharynx monocyte glomerulus blood metanephric glomerulus germinal epithelium Top expressed in blood right lung lobe granulocyte conjunctival fornix stroma of bone marrow skin of external ear vestibular sensory epithelium seminal vesicula endothelial cell of lymphatic vessel transitional epithelium of urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding WW domain binding identical protein binding receptor tyrosine kinase binding mitogen-activated protein kinase kinase kinase binding protein serine/threonine kinase activator activity Cellular component cytoplasm nucleus nuclear speck protein-containing complex Biological process positive regulation of protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9802 23994 Ensembl ENSG00000183283 ENSMUSG00000000346 UniProt Q15038 Q9DCP9 RefSeq (mRNA) NM_014764 NM_001136264 NM_001136266 NM_001136267 NM_001136268 NM_001136269 NM_011873 RefSeq (protein) NP_001129736 NP_001129738 NP_001129739 NP_001129740 NP_001129741 NP_055579 NP_036003 Location (UCSC) Chr 12: 51.24 – 51.27 Mb Chr 15: 100.51 – 100.52 Mb PubMed search [3] [4]
Wikidata
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Function

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region and is deleted in many azoospermic and severely oligospermic men. It is thought that the Y chromosomal DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL.^[7]

Interactions

DAZAP2 has been shown to interact with DAZ1.^[8]