DBC1

This article is about Deleted in bladder cancer protein 1. For breast cancer, see Deleted in Breast Cancer 1 (DBC1). For DBC 1 (radio station), see Digital Broadcasting Corporation (Hong Kong).

Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.^{[5][6][7][8][9]}

BRINP1
Identifiers
Aliases	BRINP1, DBC1, DBCCR1, FAM5A, BMP/retinoic acid inducible neural specific 1
External IDs	OMIM: 602865; MGI: 1928478; HomoloGene: 8754; GeneCards: BRINP1; OMA:BRINP1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.1 Start 119,153,458 bp[1] End 119,369,435 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C1 Start 68,679,751 bp[2] End 68,872,634 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 entorhinal cortex primary visual cortex postcentral gyrus superior frontal gyrus Brodmann area 46 prefrontal cortex frontal pole buccal mucosa cell Top expressed in visual cortex primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell hippocampus proper piriform cortex prefrontal cortex primary motor cortex subdivision of hippocampus dorsal striatum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm soma dendrite endoplasmic reticulum Biological process cell cycle negative regulation of cell cycle cell death behavioral fear response positive regulation of neuron differentiation negative regulation of neurogenesis social behavior cellular response to retinoic acid negative regulation of mitotic cell cycle short-term memory exploration behavior Maternal behavior vocalization behavior Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1620 56710 Ensembl ENSG00000078725 ENSMUSG00000028351 UniProt O60477 Q920P3 RefSeq (mRNA) NM_014618 NM_019967 RefSeq (protein) NP_055433 NP_064351 Location (UCSC) Chr 9: 119.15 – 119.37 Mb Chr 4: 68.68 – 68.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.^[7]

The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.