DBN1

Drebrin is a protein that in humans is encoded by the DBN1 gene.^[5][6]

DBN1
Identifiers
Aliases	DBN1, D0S117E, drebrin 1
External IDs	OMIM: 126660; MGI: 1931838; HomoloGene: 3236; GeneCards: DBN1; OMA:DBN1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.3 Start 177,456,608 bp[1] End 177,474,401 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 B1|13 30.06 cM Start 55,621,242 bp[2] End 55,635,924 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence sural nerve stromal cell of endometrium ventricular zone gastric mucosa ascending aorta left uterine tube Descending thoracic aorta nucleus accumbens body of uterus Top expressed in maxillary prominence mandibular prominence ventricular zone ganglionic eminence dentate gyrus of hippocampal formation granule cell superior frontal gyrus olfactory tubercle subiculum neural tube lateral septal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function profilin binding protein binding actin binding cadherin binding Cellular component cell projection membrane cell-cell junction intracellular anatomical structure cell junction dendrite cell cortex gap junction actomyosin cytoplasm growth cone plasma membrane actin cytoskeleton cytoskeleton postsynaptic density cortical cytoskeleton postsynaptic membrane glutamatergic synapse postsynaptic cytosol Biological process cell differentiation cell communication by electrical coupling regulation of dendrite development nervous system development generation of neurons multicellular organism development neural precursor cell proliferation regulation of neuronal synaptic plasticity maintenance of protein location in cell cell communication by chemical coupling actin filament organization positive regulation of synaptic plasticity cytoplasmic sequestering of protein positive regulation of dendritic spine morphogenesis positive regulation of receptor localization to synapse Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1627 56320 Ensembl ENSG00000113758 ENSMUSG00000034675 UniProt Q16643 Q9QXS6 RefSeq (mRNA) NM_004395 NM_080881 NM_001363541 NM_001364151 NM_001364152 NM_001393630 NM_001393631 NM_001177371 NM_001177372 NM_019813 RefSeq (protein) NP_004386 NP_543157 NP_001350470 NP_001351080 NP_001351081 NP_001170842 NP_001170843 NP_062787 Location (UCSC) Chr 5: 177.46 – 177.47 Mb Chr 13: 55.62 – 55.64 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.^[6]