DCAF11

DDB1- and CUL4-associated factor 11 also known as WD Repeat Domain 23 (WDR23) is a protein that in humans is encoded by the DCAF11 gene.

DCAF11
Identifiers
Aliases	DCAF11, PRO2389, WDR23, GL014, DDB1 and CUL4 associated factor 11
External IDs	OMIM: 613317; MGI: 90168; HomoloGene: 11886; GeneCards: DCAF11; OMA:DCAF11 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,114,195 bp[1] End 24,125,242 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C3|14 28.19 cM Start 55,797,463 bp[2] End 55,807,522 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver duodenum body of pancreas sural nerve skeletal muscle tissue blood granulocyte muscle of leg bone marrow gastrocnemius muscle Top expressed in left lobe of liver ankle vestibular membrane of cochlear duct right kidney muscle of thigh transitional epithelium of urinary bladder temporal muscle right ventricle sternocleidomastoid muscle triceps brachii muscle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component Cul4-RING E3 ubiquitin ligase complex nucleoplasm Biological process post-translational protein modification protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80344 28199 Ensembl ENSG00000100897 ENSG00000284796 ENSMUSG00000022214 UniProt Q8TEB1 Q91VU6 RefSeq (mRNA) NM_001163484 NM_025230 NM_181357 NM_001199009 NM_133734 RefSeq (protein) NP_001156956 NP_079506 NP_852002 NP_001185938 NP_598495 Location (UCSC) Chr 14: 24.11 – 24.13 Mb Chr 14: 55.8 – 55.81 Mb PubMed search [3] [4]
Wikidata
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DCAF11 is a WD40 repeat protein, containing seven repeats of the closed circular solenoid protein domain WD40.^[5] WDR-23 exists in two spatially distinct isoforms produced by alternative splicing, a cytoplasmic WDR-23A and nuclear WDR-23B. Nuclear and cytoplasmic versions of WDR-23 have distinct roles.^[6]