DCAF15

DDB1 and CUL4 associated factor 15 is a protein that in humans is encoded by the DCAF15 gene.^[5]

DCAF15
Identifiers
Aliases	DCAF15, C19orf72, DDB1 and CUL4 associated factor 15
External IDs	MGI: 2684420; HomoloGene: 18182; GeneCards: DCAF15; OMA:DCAF15 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 13,952,492 bp[1] End 13,961,449 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C2 Start 84,823,701 bp[2] End 84,831,397 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte left testis right testis spleen right hemisphere of cerebellum apex of heart blood skin of leg skin of abdomen right uterine tube Top expressed in otic vesicle spermatocyte seminiferous tubule otic placode saccule spermatid epiblast yolk sac thymus intestinal villus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component Cul4-RING E3 ubiquitin ligase complex protein-containing complex Biological process protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90379 212123 Ensembl ENSG00000132017 ENSG00000288453 ENSMUSG00000037103 UniProt Q66K64 Q6PFH3 RefSeq (mRNA) NM_138353 NM_172502 NM_001357322 RefSeq (protein) NP_612362 NP_766090 NP_001344251 Location (UCSC) Chr 19: 13.95 – 13.96 Mb Chr 8: 84.82 – 84.83 Mb PubMed search [3] [4]
Wikidata
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DCAF15 forms a complex with CUL4A or CUL4B that has E3 ubiquitin ligase activity and is responsible for the proteasome degradation of certain proteins.^[6]