DCDC2

Doublecortin domain-containing protein 2 (DCDC2) is a protein that in humans is encoded by the DCDC2 gene.^[5][6][7]

DCDC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DNF
Identifiers
Aliases	DCDC2, DCDC2A, DFNB66, NPHP19, RU2, RU2S, doublecortin domain containing 2, NSC
External IDs	OMIM: 605755; MGI: 2652818; HomoloGene: 9483; GeneCards: DCDC2; OMA:DCDC2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.3 Start 24,171,755 bp[1] End 24,358,059 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 25,239,987 bp[2] End 25,394,689 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte islet of Langerhans caput epididymis body of pancreas human kidney buccal mucosa cell endometrium bronchial epithelial cell pancreatic epithelial cell right uterine tube Top expressed in olfactory epithelium efferent ductule glomerulus inner renal medulla ventricular system Epithelium of choroid plexus medullary collecting duct zygote renal pelvis pancreas More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding kinesin binding Cellular component cytoplasm axoneme cell projection kinocilium cytoskeleton cytosol cilium nucleoplasm microtubule organizing center microtubule cytoskeleton mitotic spindle microtubule cortical actin cytoskeleton Biological process regulation of cilium assembly cellular defense response regulation of Wnt signaling pathway intracellular signal transduction neuron migration cell projection organization hearing positive regulation of smoothened signaling pathway nervous system development cilium assembly dendrite morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51473 195208 Ensembl ENSG00000146038 ENSMUSG00000035910 UniProt Q9UHG0 Q5DU00 RefSeq (mRNA) NM_016356 NM_001195610 NM_001195617 NM_177577 RefSeq (protein) NP_001182539 NP_057440 NP_001182546 NP_808245 Location (UCSC) Chr 6: 24.17 – 24.36 Mb Chr 13: 25.24 – 25.39 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein with two doublecortin peptide domains. This domain has been demonstrated to bind tubulin and enhance microtubule polymerization.^[7]

Clinical significance

Mutations in this gene have been associated with reading disability (RD), also referred to as developmental dyslexia.^[7][8] But this is controverse since a recent study proposed that there is a "low likelihood of a direct deletion effect on reading skills."^[9] Changes in the DCDC2 gene are frequently found among dyslexics. Altered alleles often occur among children with reading and writing difficulties. The gene appears to have a strong linkage with the processing of speech information when writing.^[10][11][12]