DCLRE1A

DNA cross-link repair 1A protein is a protein that in humans is encoded by the DCLRE1A gene.^[5][6][7]

DCLRE1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B87, 5AHR
Identifiers
Aliases	DCLRE1A, PSO2, SNM1, SNM1A, DNA cross-link repair 1A
External IDs	OMIM: 609682; MGI: 1930042; HomoloGene: 8920; GeneCards: DCLRE1A; OMA:DCLRE1A - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.3 Start 113,834,725 bp[1] End 113,854,383 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 D2 Start 56,517,599 bp[2] End 56,536,675 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte gonad testicle ventricular zone ganglionic eminence tendon of biceps brachii islet of Langerhans germinal epithelium epithelium of nasopharynx mononuclear cell Top expressed in secondary oocyte primary oocyte zygote tail of embryo genital tubercle fetal liver hematopoietic progenitor cell spermatocyte left lobe of liver lumbar subsegment of spinal cord morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 5'-3' exodeoxyribonuclease activity damaged DNA binding Cellular component fibrillar center nucleus nucleoplasm Biological process cellular response to DNA damage stimulus cell cycle double-strand break repair via nonhomologous end joining interstrand cross-link repair protection from non-homologous end joining at telomere cell division nucleic acid phosphodiester bond hydrolysis DNA repair Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9937 55947 Ensembl ENSG00000198924 ENSMUSG00000025077 UniProt Q6PJP8 Q9JIC3 RefSeq (mRNA) NM_001271816 NM_014881 NM_018831 NM_001360437 NM_001360438 NM_001360439 RefSeq (protein) NP_001258745 NP_055696 n/a Location (UCSC) Chr 10: 113.83 – 113.85 Mb Chr 19: 56.52 – 56.54 Mb PubMed search [3] [4]
Wikidata
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DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1A is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000).[supplied by OMIM]^[7]

Function

The protein DCLRE1A (DNA cross-link repair 1A) is also referred to as SNM1A (sensitive to nitrogen mustard 1A). DCLRE1A is a 5’ to 3’ exonuclease that forms a complex with the Cockayne syndrome B (CSB) protein. In this complex, CSB modulates the exonuclease activity of DCLRE1A and coordinates the efficient assembly of DCLRE1A to sites of DNA damage.^[8] In human cells, this complex is recruited to DNA inter-strand cross-links, a form of DNA damage. The complex then participates in the repair of the cross-linked DNA. DCLRE1A protein is thought to be recruited by CSB to facilitate cross-link unhooking following incision 5’ to the cross-link by another complex, the ERCC1/XPF nuclease complex.^[8] Failure of the DCLRE1A/CSB complex to carry out its repair function may contribute to the degenerative pathologies and premature aging features of Cockayne syndrome.