DCTN3

Dynactin subunit 3 is a protein that in humans is encoded by the DCTN3 gene.^[5][6][7]

DCTN3
Identifiers
Aliases	DCTN3, DCTN-22, DCTN22, dynactin subunit 3
External IDs	OMIM: 607387; MGI: 1859251; HomoloGene: 5233; GeneCards: DCTN3; OMA:DCTN3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 34,613,545 bp[1] End 34,620,523 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 41,714,798 bp[2] End 41,723,170 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence prefrontal cortex ventricular zone right frontal lobe anterior pituitary right hemisphere of cerebellum Brodmann area 9 nucleus accumbens muscle of thigh skin of leg Top expressed in saccule medial ganglionic eminence otic vesicle otic placode superior frontal gyrus facial motor nucleus right kidney primary visual cortex motor neuron choroid plexus of fourth ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity protein binding Cellular component cytoplasm centrosome dynactin complex spindle chromosome microtubule organizing center microtubule associated complex midbody perinuclear region of cytoplasm cleavage furrow chromosome, centromeric region cytoskeleton kinetochore nucleolus cytosol microtubule Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II cell division endoplasmic reticulum to Golgi vesicle-mediated transport G2/M transition of mitotic cell cycle microtubule-based process cell cycle ciliary basal body-plasma membrane docking mitotic cell cycle regulation of G2/M transition of mitotic cell cycle cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11258 53598 Ensembl ENSG00000137100 ENSMUSG00000028447 UniProt O75935 Q9Z0Y1 RefSeq (mRNA) NM_024348 NM_001281425 NM_001281426 NM_001281427 NM_007234 NM_001159565 NM_016890 RefSeq (protein) NP_001268354 NP_001268355 NP_001268356 NP_009165 NP_077324 NP_001153037 NP_058586 Location (UCSC) Chr 9: 34.61 – 34.62 Mb Chr 4: 41.71 – 41.72 Mb PubMed search [3] [4]
Wikidata
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This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants.^[7]