DDOST

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase 48 kDa subunit is an enzyme that in humans is encoded by the DDOST gene.^[5][6]

DDOST
Identifiers
Aliases	DDOST, AGER1, CDG1R, OKSWcl45, OST, OST48, WBP1, dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit, GATD6
External IDs	OMIM: 602202; MGI: 1194508; HomoloGene: 3821; GeneCards: DDOST; OMA:DDOST - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 20,651,767 bp[1] End 20,661,544 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 138,032,041 bp[2] End 138,039,939 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis stromal cell of endometrium body of pancreas caput epididymis islet of Langerhans rectum smooth muscle tissue placenta beta cell spleen Top expressed in parotid gland lacrimal gland seminal vesicula gastrula dermis islet of Langerhans molar stroma of bone marrow vestibular sensory epithelium crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function dolichyl-diphosphooligosaccharide-protein glycotransferase activity protein binding oligosaccharyl transferase activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle endoplasmic reticulum oligosaccharyltransferase complex plasma membrane azurophil granule membrane protein-containing complex Biological process response to cytokine protein N-linked glycosylation via asparagine protein glycosylation protein N-linked glycosylation T cell activation neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1650 13200 Ensembl ENSG00000244038 ENSMUSG00000028757 UniProt P39656 O54734 RefSeq (mRNA) NM_005216 NM_007838 RefSeq (protein) NP_005207 NP_031864 Location (UCSC) Chr 1: 20.65 – 20.66 Mb Chr 4: 138.03 – 138.04 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.^[6]