DDT (gene)

D-dopachrome decarboxylase is an enzyme that in humans is encoded by the DDT gene.^[5][6][7]

DDT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Q3F, 3KAN, 1DPT
Identifiers
Aliases	DDT, DDCT, D-dopachrome tautomerase, MIF-2, MIF2, D-DT
External IDs	OMIM: 602750; MGI: 1298381; HomoloGene: 1038; GeneCards: DDT; OMA:DDT - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.23 Start 23,971,365 bp[1] End 23,979,828 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 38.58 cM Start 75,607,064 bp[2] End 75,609,248 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver mucosa of transverse colon body of pancreas human kidney apex of heart body of stomach left ventricle fundus olfactory zone of nasal mucosa right adrenal gland Top expressed in right kidney proximal tubule spermatocyte yolk sac human kidney embryo testicle white adipose tissue epiblast liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function dopachrome isomerase activity D-dopachrome decarboxylase activity lyase activity cytokine receptor binding phenylpyruvate tautomerase activity Cellular component cytoplasm extracellular exosome extracellular space Biological process melanin biosynthetic process negative regulation of macrophage chemotaxis positive regulation of tumor necrosis factor production positive regulation of inflammatory response positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1652 13202 Ensembl ENSG00000099977 ENSG00000275003 ENSMUSG00000001666 UniProt P30046 O35215 RefSeq (mRNA) NM_001084392 NM_001355 NM_001381852 NM_001397485 NM_010027 RefSeq (protein) NP_001077861 NP_001346 NP_001368781 NP_034157 Location (UCSC) Chr 22: 23.97 – 23.98 Mb Chr 10: 75.61 – 75.61 Mb PubMed search [3] [4]
Wikidata
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D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the macrophage migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.^[7]

See also

• Macrophage migration inhibitory factor domain