DDX1

ATP-dependent RNA helicase DDX1 is an enzyme that in humans is encoded by the DDX1 gene.^[5][6]

DDX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XW3
Identifiers
Aliases	DDX1, DBP-RB, UKVH5d, DEAD/H-box helicase 1, DEAD-box helicase 1
External IDs	OMIM: 601257; MGI: 2144727; HomoloGene: 3627; GeneCards: DDX1; OMA:DDX1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p24.3 Start 15,591,178 bp[1] End 15,634,346 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.1 Start 13,266,974 bp[2] End 13,299,214 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of biceps brachii right ventricle deltoid muscle triceps brachii muscle middle temporal gyrus tendon of biceps brachii parotid gland glutes Skeletal muscle tissue of rectus abdominis islet of Langerhans Top expressed in primitive streak spermatid spermatocyte ventricular zone epiblast maxillary prominence mandibular prominence dentate gyrus of hippocampal formation granule cell triceps brachii muscle temporal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA helicase activity DNA binding nucleotide binding helicase activity poly(A) binding chromatin binding transcription coregulator activity DNA/RNA helicase activity protein binding nucleic acid binding nuclease activity double-stranded RNA binding exonuclease activity hydrolase activity ATP binding RNA binding Cellular component cytoplasm membrane nucleoplasm tRNA-splicing ligase complex cytoplasmic stress granule cleavage body nucleus cytosol nucleolus mitochondrion ribonucleoprotein complex Biological process regulation of transcription, DNA-templated response to exogenous dsRNA mRNA processing response to virus protein localization to cytoplasmic stress granule transcription, DNA-templated multicellular organism development spliceosomal complex assembly DNA duplex unwinding double-strand break repair RNA secondary structure unwinding regulation of translational initiation tRNA splicing, via endonucleolytic cleavage and ligation tRNA processing nucleic acid phosphodiester bond hydrolysis immune system process positive regulation of myeloid dendritic cell cytokine production positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response defense response to virus regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1653 104721 Ensembl ENSG00000079785 ENSMUSG00000037149 UniProt Q92499 Q91VR5 RefSeq (mRNA) NM_004939 NM_134040 RefSeq (protein) NP_004930 NP_598801 Location (UCSC) Chr 2: 15.59 – 15.63 Mb Chr 12: 13.27 – 13.3 Mb PubMed search [3] [4]
Wikidata
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Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin.^[6]

Interactions

DDX1 has been shown to interact with HNRPK.^[7] DDX1 has also been tentatively shown to interact with hCLE/C14orf166/RTRAF and HSPC117 in a cap-binding complex that activates mRNA translation. ^[8]