DDX21

Nucleolar RNA helicase 2 is an enzyme that in humans is encoded by the DDX21 gene.^[5][6]

DDX21
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M3D
Identifiers
Aliases	DDX21, GUA, GURDB, RH-II/GU, RH-II/GuA, DEAD-box helicase 21, DExD-box helicase 21
External IDs	OMIM: 606357; MGI: 1860494; HomoloGene: 3473; GeneCards: DDX21; OMA:DDX21 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.1 Start 68,956,135 bp[1] End 68,985,068 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B4|10 32.43 cM Start 62,416,030 bp[2] End 62,438,060 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium cartilage tissue mucosa of urinary bladder mucosa of pharynx gingival epithelium vena cava lower lobe of lung nipple lactiferous duct human penis Top expressed in epiblast cumulus cell somite primitive streak tail of embryo hair follicle mandibular prominence maxillary prominence abdominal wall ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding rRNA binding helicase activity 7SK snRNA binding protein binding nucleic acid binding double-stranded RNA binding hydrolase activity ATP binding snoRNA binding RNA binding miRNA binding identical protein binding Cellular component membrane nucleoplasm nucleus nucleolus cytoplasm mitochondrion cytosol Biological process epigenetic maintenance of chromatin in transcription-competent conformation response to exogenous dsRNA response to virus transcription by RNA polymerase II transcription, DNA-templated osteoblast differentiation RNA secondary structure unwinding rRNA processing immune system process positive regulation of myeloid dendritic cell cytokine production positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response defense response to virus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9188 56200 Ensembl ENSG00000165732 ENSMUSG00000020075 UniProt Q9NR30 Q9JIK5 RefSeq (mRNA) NM_001256910 NM_004728 NM_019553 RefSeq (protein) NP_001243839 NP_004719 NP_062426 Location (UCSC) Chr 10: 68.96 – 68.99 Mb Chr 10: 62.42 – 62.44 Mb PubMed search [3] [4]
Wikidata
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Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.^[6]

Interactions

DDX21 has been shown to interact with C-jun.^[7]