DDX23

Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene.^[5][6][7]

DDX23
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4NHO, 3JCR
Identifiers
Aliases	DDX23, PRPF28, SNRNP100, U5-100K, U5-100KD, prp28, DEAD-box helicase 23
External IDs	OMIM: 612172; MGI: 1921601; HomoloGene: 3542; GeneCards: DDX23; OMA:DDX23 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 48,829,756 bp[1] End 48,852,842 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F1 Start 98,543,015 bp[2] End 98,560,775 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve granulocyte ventricular zone right uterine tube body of stomach ganglionic eminence rectum right lobe of thyroid gland transverse colon Top expressed in neural layer of retina ventricular zone muscle of thigh yolk sac tail of embryo esophagus superior frontal gyrus genital tubercle dentate gyrus of hippocampal formation granule cell lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding helicase activity protein binding nucleic acid binding hydrolase activity ATP binding RNA binding Cellular component catalytic step 2 spliceosome U5 snRNP nucleoplasm spliceosomal complex extracellular exosome nucleus nucleolus cytoplasm Biological process mRNA splicing, via spliceosome RNA splicing, via transesterification reactions mRNA processing RNA secondary structure unwinding RNA splicing cis assembly of pre-catalytic spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9416 74351 Ensembl ENSG00000174243 ENSMUSG00000003360 UniProt Q9BUQ8 n/a RefSeq (mRNA) NM_004818 NM_001080981 RefSeq (protein) NP_004809 n/a Location (UCSC) Chr 12: 48.83 – 48.85 Mb Chr 15: 98.54 – 98.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined.^[7]