DDX24

ATP-dependent RNA helicase DDX24 is an enzyme that in humans is encoded by the DDX24 gene.^[5][6]

DDX24
Identifiers
Aliases	DDX24, DEAD-box helicase 24
External IDs	OMIM: 606181; MGI: 1351337; HomoloGene: 10702; GeneCards: DDX24; OMA:DDX24 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.12 Start 94,048,287 bp[1] End 94,081,202 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 103,374,241 bp[2] End 103,392,089 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis superior frontal gyrus left testis anterior pituitary primary visual cortex prefrontal cortex Brodmann area 9 hypothalamus right frontal lobe left adrenal gland Top expressed in spermatocyte spermatid dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus neural layer of retina muscle of thigh embryo yolk sac tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA helicase activity nucleotide binding hydrolase activity ATP binding helicase activity nucleic acid binding RNA binding Cellular component membrane nucleolus cytoplasm Biological process RNA metabolic process RNA secondary structure unwinding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57062 27225 Ensembl ENSG00000089737 ENSMUSG00000041645 UniProt Q9GZR7 Q9ESV0 RefSeq (mRNA) NM_020414 NM_001159502 NM_020494 NM_001364162 NM_001364163 RefSeq (protein) NP_065147 NP_001152974 NP_065240 NP_001351091 NP_001351092 Location (UCSC) Chr 14: 94.05 – 94.08 Mb Chr 12: 103.37 – 103.39 Mb PubMed search [3] [4]
Wikidata
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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial RNA splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level.^[6]