DDX27

DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, also known as DDX27, is a human gene.^[5]

DDX27
Identifiers
Aliases	DDX27, DRS1, Drs1p, PP3241, RHLP, dJ686N3.1, HSPC259, DEAD-box helicase 27
External IDs	OMIM: 616621; MGI: 2385884; HomoloGene: 6431; GeneCards: DDX27; OMA:DDX27 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.13 Start 49,219,347 bp[1] End 49,244,077 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 166,857,113 bp[2] End 166,876,867 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii pancreatic ductal cell endothelial cell sural nerve hair follicle mucosa of ileum left ovary right ovary pylorus sperm Top expressed in epiblast otic placode primitive streak yolk sac tail of embryo embryo otic vesicle morula saccule embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding hydrolase activity ATP binding helicase activity nucleic acid binding RNA binding Cellular component nucleolus nucleus chromosome cytoplasm Biological process rRNA processing RNA secondary structure unwinding ribosome biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55661 228889 Ensembl ENSG00000124228 ENSMUSG00000017999 UniProt Q96GQ7 Q921N6 RefSeq (mRNA) NM_017895 NM_001348187 NM_153065 RefSeq (protein) NP_060365 NP_001335116 NP_694705 Location (UCSC) Chr 20: 49.22 – 49.24 Mb Chr 2: 166.86 – 166.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the family of DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, the function of which has not been determined.^[5]