DDX56

Probable ATP-dependent RNA helicase DDX56 is an enzyme that in humans is encoded by the DDX56 gene.^[5][6]

DDX56
Identifiers
Aliases	DDX56, DDX21, DDX26, NOH61, DEAD-box helicase 56
External IDs	OMIM: 608023; MGI: 1277172; HomoloGene: 6498; GeneCards: DDX56; OMA:DDX56 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 44,565,804 bp[1] End 44,575,051 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 3.94 cM Start 6,208,919 bp[2] End 6,217,772 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum right lobe of thyroid gland left lobe of thyroid gland mucosa of transverse colon anterior pituitary right ovary left ovary granulocyte right lobe of liver Top expressed in otic placode otic vesicle saccule blastocyst morula embryo embryo epiblast spermatocyte yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding hydrolase activity ATP binding helicase activity nucleic acid binding RNA binding Cellular component membrane nucleus nucleolus cytoplasm Biological process rRNA processing RNA secondary structure unwinding ribosome biogenesis positive regulation of neuron projection development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54606 52513 Ensembl ENSG00000136271 ENSMUSG00000004393 UniProt Q9NY93 Q9D0R4 RefSeq (mRNA) NM_019082 NM_001257189 NM_026538 RefSeq (protein) NP_001244118 NP_061955 NP_080814 Location (UCSC) Chr 7: 44.57 – 44.58 Mb Chr 11: 6.21 – 6.22 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit.^[6]