DDX6

Probable ATP-dependent RNA helicase DDX6 is an enzyme that in humans is encoded by the DDX6 gene.^[5][6]

DDX6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VEC, 2WAX, 2WAY, 4CRW, 4CT4, 4CT5, 5ANR
Identifiers
Aliases	DDX6, HLR2, P54, RCK, DEAD-box helicase 6, IDDILF, Rck/p54
External IDs	OMIM: 600326; MGI: 104976; HomoloGene: 3238; GeneCards: DDX6; OMA:DDX6 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 118,747,763 bp[1] End 118,791,164 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.2|9 24.84 cM Start 44,516,189 bp[2] End 44,552,028 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Achilles tendon ventricular zone middle temporal gyrus superior vestibular nucleus amniotic fluid internal globus pallidus vena cava lateral nuclear group of thalamus trigeminal ganglion Top expressed in aortic valve ascending aorta gastrula saccule otic placode supraoptic nucleus mesenteric lymph nodes otic vesicle lacrimal gland superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA helicase activity nucleotide binding helicase activity protein domain specific binding protein binding nucleic acid binding hydrolase activity ATP binding RNA binding cadherin binding Cellular component cytoplasm RISC complex membrane P-body cytoplasmic stress granule mitochondrion sperm annulus P granule outer dense fiber heterochromatin nucleus cytosol nucleolus cytoplasmic ribonucleoprotein granule chromatoid body perinuclear region of cytoplasm concave side of sperm head Biological process negative regulation of neuron differentiation stem cell population maintenance RNA secondary structure unwinding P-body assembly exonucleolytic catabolism of deadenylated mRNA viral RNA genome packaging regulation of translation spermatogenesis spermatid differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1656 13209 Ensembl ENSG00000110367 ENSMUSG00000032097 UniProt P26196 P54823 RefSeq (mRNA) NM_001257191 NM_004397 NM_001110826 NM_007841 NM_181324 NM_001357702 NM_001357703 RefSeq (protein) NP_001244120 NP_004388 NP_001104296 NP_031867 NP_851841 NP_001344631 NP_001344632 Location (UCSC) Chr 11: 118.75 – 118.79 Mb Chr 9: 44.52 – 44.55 Mb PubMed search [3] [4]
Wikidata
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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein. It may contribute to the cell proliferation and carcinogenesis.^[6]