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DENND1B

Human gene From Wikipedia, the free encyclopedia

DENND1B
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DENN domain-containing protein 1B is a protein encoded by DENND1B human gene, located on chromosome 1.

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Structure

The protein has tripartite DENN domain at N-terminal.

Functions

The protein is a guanine nucleotide exchange factor for RAB35.[5]

Clinical significance

The gene is hypothesized by Danish scientists Klaus Bønnelykke and Hans Bisgaard to be related to asthma.[6] The gene may affect susceptibility to chronic cavitary pulmonary aspergillosis.[7] Variants of this gene are also associated with obesity in both humans and dogs.[8]

References

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