DGKA

Diacylglycerol kinase alpha is an enzyme that in humans is encoded by the DGKA gene.^[5][6][7]

DGKA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TUZ
Identifiers
Aliases	DGKA, DAGK, DAGK1, DGK-alpha, diacylglycerol kinase alpha
External IDs	OMIM: 125855; MGI: 102952; HomoloGene: 1028; GeneCards: DGKA; OMA:DGKA - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 55,927,319 bp[1] End 55,954,027 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D3|10 77.14 cM Start 128,556,003 bp[2] End 128,580,724 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg granulocyte spleen lymph node mucosa of transverse colon minor salivary glands olfactory zone of nasal mucosa tonsil rectum Top expressed in thymus lymph node corneal stroma mesenteric lymph nodes blood spleen spermatid granulocyte colon left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding calcium ion binding phospholipid binding ATP binding metal ion binding kinase activity diacylglycerol kinase activity NAD+ kinase activity Cellular component cytosol plasma membrane membrane intracellular anatomical structure Biological process platelet activation protein kinase C-activating G protein-coupled receptor signaling pathway intracellular signal transduction phosphorylation glycerolipid metabolic process phosphatidic acid biosynthetic process diacylglycerol metabolic process lipid phosphorylation metabolism signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1606 13139 Ensembl ENSG00000065357 ENSMUSG00000025357 UniProt P23743 O88673 RefSeq (mRNA) NM_001345 NM_201444 NM_201445 NM_201554 NM_001351033 NM_001351034 NM_001351035 NM_001351036 NM_001351037 NM_001351038 NM_001351039 NM_001351040 NM_016811 NM_001358745 NM_001358746 NM_001372366 NM_001374028 RefSeq (protein) NP_001336 NP_958852 NP_958853 NP_963848 NP_001337962 NP_001337963 NP_001337964 NP_001337965 NP_001337966 NP_001337967 NP_001337968 NP_001337969 NP_058091 NP_001345674 NP_001345675 NP_001359295 NP_001360957 Location (UCSC) Chr 12: 55.93 – 55.95 Mb Chr 10: 128.56 – 128.58 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.^[7]