DGKG

Diacylglycerol kinase gamma is an enzyme that in humans is encoded by the DGKG gene.^[5][6]

DGKG
Identifiers
Aliases	DGKG, DAGK3, DGK-GAMMA, diacylglycerol kinase gamma
External IDs	OMIM: 601854; MGI: 105060; HomoloGene: 1029; GeneCards: DGKG; OMA:DGKG - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.2-q27.3 Start 186,105,668 bp[1] End 186,362,234 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 B1|16 13.37 cM Start 22,287,211 bp[2] End 22,475,971 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum buccal mucosa cell gastric mucosa monocyte cingulate gyrus anterior cingulate cortex left ventricle apex of heart Top expressed in subiculum dentate gyrus of hippocampal formation granule cell lobe of cerebellum lateral septal nucleus hippocampus proper cerebellar vermis granulocyte anterior amygdaloid area piriform cortex pontine nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding calcium ion binding ATP binding metal ion binding kinase activity diacylglycerol kinase activity NAD+ kinase activity Cellular component cytoplasm plasma membrane membrane Biological process platelet activation protein kinase C-activating G protein-coupled receptor signaling pathway intracellular signal transduction neuron development phosphorylation glycerolipid metabolic process lipid phosphorylation metabolism signal transduction diacylglycerol metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1608 110197 Ensembl ENSG00000058866 ENSMUSG00000022861 UniProt P49619 Q91WG7 RefSeq (mRNA) NM_001346 NM_001080744 NM_001080745 NM_138650 NM_001346673 RefSeq (protein) NP_001074213 NP_001074214 NP_001337 NP_001333602 NP_619591 Location (UCSC) Chr 3: 186.11 – 186.36 Mb Chr 16: 22.29 – 22.48 Mb PubMed search [3] [4]
Wikidata
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This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene.^[6]