DGKZ

Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.^[5][6]

DGKZ
Identifiers
Aliases	DGKZ, DAGK5, DAGK6, DGK-ZETA, hDGKzeta, diacylglycerol kinase zeta
External IDs	OMIM: 601441; MGI: 1278339; HomoloGene: 37831; GeneCards: DGKZ; OMA:DGKZ - orthologs
EC number	2.7.1.107
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 46,332,905 bp[1] End 46,380,554 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E1 Start 91,763,169 bp[2] End 91,806,209 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe cingulate gyrus anterior cingulate cortex granulocyte Brodmann area 9 apex of heart gastrocnemius muscle right hemisphere of cerebellum muscle of thigh anterior pituitary Top expressed in lobe of cerebellum cerebellar vermis primary motor cortex internal carotid artery cingulate gyrus prefrontal cortex Paneth cell subdivision of hippocampus Region I of hippocampus proper temporal lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding lipid kinase activity metal ion binding protein C-terminus binding protein binding ATP binding kinase activity diacylglycerol kinase activity NAD+ kinase activity Cellular component membrane plasma membrane nucleus lamellipodium cytoplasm nuclear speck postsynaptic density glutamatergic synapse cell projection Biological process intracellular signal transduction platelet activation protein kinase C-activating G protein-coupled receptor signaling pathway mitotic G1 DNA damage checkpoint signaling cell migration negative regulation of mitotic cell cycle glycerolipid metabolic process phosphorylation diacylglycerol metabolic process lipid phosphorylation metabolism signal transduction phosphatidic acid biosynthetic process positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8525 104418 Ensembl ENSG00000149091 ENSMUSG00000040479 UniProt Q13574 Q80UP3 RefSeq (mRNA) NM_001105540 NM_001199266 NM_001199267 NM_001199268 NM_003646 NM_201532 NM_201533 NM_001166597 NM_138306 RefSeq (protein) NP_001099010 NP_001186195 NP_001186196 NP_001186197 NP_003637 NP_963290 NP_963291 NP_001160069 NP_612179 Location (UCSC) Chr 11: 46.33 – 46.38 Mb Chr 2: 91.76 – 91.81 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.^[6]

Interactions

DGKZ has been shown to interact with P110α.^[7]