DHRSX

Dehydrogenase/reductase (SDR family) X-linked also known as DHRSX is an enzyme which in humans is encoded by the pseudoautosomal DHRSX gene.^[4] DHRSX is a member of the short-chain dehydrogenase family of oxidoreductase enzymes.^[5]

DHRSX
Identifiers
Aliases	DHRSX, CXorf11, DHRS5X, DHRS5Y, DHRSXY, DHRSY, SDR46C1, SDR7C6, dehydrogenase/reductase (SDR family) X-linked, dehydrogenase/reductase X-linked
External IDs	MGI: 2181510; HomoloGene: 78041; GeneCards: DHRSX; OMA:DHRSX - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.33 and Yp11.2 Start 2,219,506 bp[1] End 2,502,805 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ventricular zone ganglionic eminence body of pancreas apex of heart right atrium right auricle of heart right lobe of liver gastrocnemius muscle left ventricle n/a More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity Cellular component extracellular region Biological process positive regulation of autophagy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 207063 236082 Ensembl ENSG00000169084 ENSMUSG00000063897 UniProt Q8N5I4 Q8VBZ0 RefSeq (mRNA) NM_145177 NM_001033326 RefSeq (protein) NP_660160 n/a Location (UCSC) Chr X: 2.22 – 2.5 Mb n/a PubMed search [2] [3]
Wikidata
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DHRSX is required for two steps in the biosynthesis of dolichol: i) the NAD⁺-dependent conversion of polyprenol to its aldehyde analogue, polyprenal; ii) the NADPH-dependent reduction of dolichal to dolichol.^[6] Dolichol is a long polyisoprenoid lipid required as the carrier of mono- and oligosaccharides in the processes of N-glycosylation, C-/O-mannosylation and the formation of glycosylphosphatidylinositol (GPI) anchors.