DHX15

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 is an enzyme that in humans is encoded by the DHX15 gene.^[5][6]

DHX15
Identifiers
Aliases	DHX15, DBP1, DDX15, HRH2, PRP43, PRPF43, PrPp43p, DEAH-box helicase 15, hPrp43
External IDs	OMIM: 603403; MGI: 1099786; HomoloGene: 1040; GeneCards: DHX15; OMA:DHX15 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.2 Start 24,517,441 bp[1] End 24,584,554 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C1 Start 52,307,545 bp[2] End 52,347,856 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue tibia germinal epithelium mucosa of sigmoid colon visceral pleura skin of hip parietal pleura embryo ventricular zone skin of thigh Top expressed in primitive streak Gonadal ridge mandibular prominence maxillary prominence abdominal wall hair follicle medial ganglionic eminence cumulus cell human fetus somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA helicase activity nucleotide binding double-stranded RNA binding protein binding ATP binding helicase activity hydrolase activity nucleic acid binding RNA binding 3'-5' RNA helicase activity Cellular component U12-type spliceosomal complex nucleolus U2-type post-mRNA release spliceosomal complex cytoplasm nucleus nucleoplasm nuclear speck Biological process mRNA processing response to alkaloid response to toxic substance RNA splicing mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1665 13204 Ensembl ENSG00000109606 ENSMUSG00000029169 UniProt O43143 O35286 RefSeq (mRNA) NM_001358 NM_001042620 NM_007839 RefSeq (protein) NP_001349 NP_001036085 NP_031865 Location (UCSC) Chr 4: 24.52 – 24.58 Mb Chr 5: 52.31 – 52.35 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing.^[6] It may have tumor suppressor activity.^[7]